Biochip – based test systems are a simple and state-of-the-art tool for instant differential cancer diagnosis, target search for therapeutic purposes and evaluation of the disease prognosis

 

Biochip-based test systems for immunocytochemical analysis are a simple and state-of-the-art tool for instant differential diagnosis of malignant tumours in a human body, as well as target search for drug treatment.

 

Their advantages include great accuracy of obtained results (no less than 96%), minimum analysis time (60 minutes), the fact that no morphologist is required in the staff structure of a medical institution, the possibility of remote consultation in terms of the analysis results with the participation of an experienced specialist, and a low cost for the end user.

Biochips used in clinical practice enable you:
To make histogenetic diagnosis of tumours
To define the nosological variant of a growth
To detect the primary tumour by metastasis with an unknown primary site
To predict tumour development
To recognise a malignant transformation of cells
To form the basis for targeted therapy
To evaluate the resistance or sensitivity of tumour cells to chemotherapeutic and target compounds

 

The diagnosis process with the help of a biochip is based on the principle of direct fluorescent immunocytochemistry with subsequent morphological analysis.

We presently offer 7 types of test systems:

 

 «ЕРН» BiochipFor determining the immunophenotype of breast cancer cells;

 

List of markers
Рецепторы эстрогена (РЭ)
Рецепторы прогестерона (РGR)
Her2-neu (EGFR 2)
EGFR
Ki67

 

 

«SER» Biochipdetermining the nature of the serous fluid;

 

List of markers
СА-125
РЭА
Цитокератин 7 (СК7)
Цитокератин 20 (СК 20)
РЭ (ER)
TTF
WT-1
BerEp4
Виментин (VIM)

 

«TYR» Biochip for differential diagnosis of thyroid neoplasms ;

 

List of markers
Тиреоглобулин (TG)
Кальцитонин (CT)
TTF1
Галектин 3 (GAL 3)
Мезотелиальный антиген НВМЕ1
Цитокератин 19 (СК19)
CD44v6 (HCAM)
p53

 

 «Pulmo» BiochipFor diagnosing lung cancer;

 

List of markers
СК7
СК 20
TTF1
Хромогранин А
Cинаптофизин
p53
CD 56
СК5/6
р63

 

«PNV» BiochipFor diagnosing malignant tumours in the genitourinary tract;

 

List of markers
р16 (CDKN2A)
Ki67
р63
Цитокератины 5/6 (СК5/6)
CK7
CK 20
СА125
WT1
Уроплакин (UPK3А)
FAS (CD95)
CDX2

 

«NOD1» BiochipTo search for an undetected primary site;

 

List of markers
РЭ (ER)
СК7
СК20
ПСА (PSA)
Кальретинин (СR)
Хромогранин А
CD56 (NCAM)
CD10 (NEP)
CD44 (HCAM)
CK19
RCC
TTF1
ЭМА
Тиреоглобулин (TG)
CDX2

 

«NOD2» BiochipTo search for an undetected primary site.

 

List of markers
СК7
СК20
CD138 (SDC1)
Виментин (VIM)
ЕрСam
CD99
S100
Десмин
ЭМА
Мелан А (MLANA)
НМВ 45 (ME20M)
РЭА
HBME1
Остеонектин (ОN)
Остеокальцин (OC)

 

A standard biochip has compartments covered with a protective film. These compartments contain fluorescent-labelled proteins.

biochip
Design of a biochip-based test system.