Immunocytochemistry studies specific antigenic features of normal and malignant transformed cells. Immunocytochemical methods are aimed at immunological analysis of the cytologic material with preserved cell morphology. ICC methods enable specific detection of membrane and intracellular structures (antigens) with the help of (fluorescent or enzyme) labelled antibodies and are the key component of the current cancer diagnosis procedure. In the field of clinical oncology ICC methods permit to characterize every detail of the molecular portrait of a tumour associated with the differentiation degree of malignant cells, their metastatic potential, detection of the source of metastasis in case of an unknown primary site, the sensitivity or resistance to the conducted therapy, and a personalised prognosis of the course of disease for a particular patient.
Biochips make it clinically possible:
- to make histogenetic diagnosis of tumours;
- to define the nosological variant of a growth;
- to detect the primary tumour by metastasis with an unknown primary site;
- to make a prognosis of tumour development;
- to recognise a malignant transformation of cells;
- to find grounds for prescribing targeted therapy,
- to analyse both the resistance and sensitivity of tumour cells to chemotherapeutic and target compounds.
The technology of RDC Biochip is perfectly suitable for such fields of oncology as